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Most people who report that sublingual peptides "do not work" are making technique errors that dramatically reduce bioavailability

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3.7 Therapeutic controversies over use of selenium supplement during cancer treatment Selenium decreases inflammation, prevents DNA damage, controls the production of active thyroid hormone, and regulates a wide range of biological functions, including cell membrane and integrity energy metabolism (13)

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But its more than just your metabolism (metabolic rate) slowing several factors lead to weight gain during hypothyroidism